Ramifications of multigene comparison

• No variant recognized.
• VUS imagined.
• Pathogenic version during the a high-penetrance gene concordant into the established private/genealogy and family history (age.grams., good germline MSH2 pathogenic version inside the someone who matches Amsterdam criteria for Lynch syndrome).
• Pathogenic version when you look at the a leading-penetrance gene discordant with the current individual/genealogy (elizabeth.grams., a good germline CDH1 pathogenic version from inside the one no personal/genealogy of gastric cancers). Читать далее →